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| 产品: | CCL21 抗体 |
| 货号: | DF6681 |
| 描述: | Rabbit polyclonal antibody to CCL21 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 15kDa; 15kD(Calculated). |
| 蛋白号: | O00585 |
| RRID: | AB_2838643 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6681, RRID:AB_2838643.
展开/折叠
6Ckine; Beta-chemokine exodus-2; C C motif chemokine ligand 21; C-C motif chemokine 21; CCL21; CCL21_HUMAN; Chemokine (C-C motif) ligand 21; Chemokine CC motif ligand 21; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; SCYA21; Secondary lymphoid-tissue chemokine; SLC; Small inducible cytokine A21; Small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21; TCA4; UNQ784/PRO1600;
抗原和靶标
Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
- O00585 CCL21_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP
翻译修饰 - O00585 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K114 | Acetylation | Uniprot | |
| K115 | Acetylation | Uniprot | |
| K115 | Methylation | Uniprot | |
| K117 | Acetylation | Uniprot | |
| K117 | Methylation | Uniprot | |
| K120 | Acetylation | Uniprot | |
| K120 | Methylation | Uniprot | |
| K123 | Methylation | Uniprot |
研究背景
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Secreted.
Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Monomer. Binds to CCR7. Interacts with PDPN; relocalizes PDPN to the basolateral membrane.
Belongs to the intercrine beta (chemokine CC) family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
文献引用
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