产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6691, RRID:AB_2838653.
展开/折叠
Epididymis secretory sperm binding protein Li 2a; HEL S 2a; MGC4104; Natural killer cell enhancing factor B; Natural killer cell-enhancing factor B; Natural Killer Enhancing Factor B; NKEF B; NKEF-B; NKEFB; Peroxiredoxin-2; PRDX 2; PRDX2; PRDX2_HUMAN; PrP; PRX2; PRXII; PTX1; TDPX1; Thiol Specific Antioxidant 1; Thiol specific antioxidant protein; Thiol-specific antioxidant protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Torin; TPX1; TSA;
抗原和靶标
- P32119 PRDX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P32119 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
A2 | Acetylation | Uniprot | |
S3 | Phosphorylation | Uniprot | |
K10 | Ubiquitination | Uniprot | |
K16 | Acetylation | Uniprot | |
K16 | Ubiquitination | Uniprot | |
T18 | O-Glycosylation | Uniprot | |
T18 | Phosphorylation | Uniprot | |
K26 | Acetylation | Uniprot | |
K26 | Ubiquitination | Uniprot | |
K29 | Ubiquitination | Uniprot | |
S31 | Phosphorylation | Uniprot | |
K34 | Acetylation | Uniprot | |
T89 | Phosphorylation | Uniprot | |
K92 | Ubiquitination | Uniprot | |
R110 | Methylation | Uniprot | |
S112 | O-Glycosylation | Uniprot | |
S112 | Phosphorylation | Uniprot | |
Y115 | Phosphorylation | Uniprot | |
K119 | Acetylation | Uniprot | |
K119 | Ubiquitination | Uniprot | |
T120 | Phosphorylation | Uniprot | |
Y126 | Phosphorylation | Uniprot | |
R127 | Methylation | Uniprot | |
K135 | Acetylation | Uniprot | |
K135 | Ubiquitination | Uniprot | |
T142 | Phosphorylation | Uniprot | |
R150 | Methylation | Uniprot | |
S151 | Phosphorylation | Uniprot | |
R157 | Methylation | Uniprot | |
K177 | Methylation | Uniprot | |
K177 | Ubiquitination | Uniprot | |
T182 | Phosphorylation | Uniprot | |
S190 | Phosphorylation | Uniprot | |
K191 | Sumoylation | Uniprot | |
K191 | Ubiquitination | Uniprot | |
Y193 | Phosphorylation | Uniprot | |
S195 | Phosphorylation | Uniprot |
研究背景
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
Cytoplasm.
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. Interacts with TIPIN.
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
文献引用
Application: WB Species: Human Sample: Wound granulation tissues
Application: WB Species: Human Sample: Wound granulation tissues
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