| 产品: | TNNC1 抗体 |
| 货号: | DF6697 |
| 描述: | Rabbit polyclonal antibody to TNNC1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 18kDa; 18kD(Calculated). |
| 蛋白号: | P63316 |
| RRID: | AB_2838659 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6697, RRID:AB_2838659.
展开/折叠
tnnc1a; Cardiac troponin C; slow skeletal and cardiac muscles; TN-C; TNC; Tnnc1; TNNC1_HUMAN; TNNI3; Troponin C; Troponin C slow; Troponin C1 slow;
抗原和靶标
- P63316 TNNC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P63316 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K6 | Acetylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K21 | Acetylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| Y111 | Phosphorylation | Uniprot |
研究背景
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Belongs to the troponin C family.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
限制条款
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