产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6703, RRID:AB_2838665.
展开/折叠
BAG9; Cancer associated surface antigen; Cancer associated surface antigen RCAS1; Cancer-associated surface antigen RCAS1; EB9; EBAG 9; EBAG9; Estrogen receptor binding fragment associated gene 9 protein; Estrogen receptor binding site associated antigen 9; estrogen receptor binding site associated, antigen, 9; Estrogen receptor-binding fragment-associated gene 9 protein; PDAF; RCAS 1; RCAS1; RCAS1_HUMAN; Receptor binding cancer antigen expressed on SiSo cells; Receptor-binding cancer antigen expressed on SiSo cells;
抗原和靶标
Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
- O00559 RCAS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAITQFRLFKFCTCLATVFSFLKRLICRSGRGRKLSGDQITLPTTVDYSSVPKQTDVEEWTSWDEDAPTSVKIEGGNGNVATQQNSLEQLEPDYFKDMTPTIRKTQKIVIKKREPLNFGIPDGSTGFSSRLAATQDLPFIHQSSELGDLDTWQENTNAWEEEEDAAWQAEEVLRQQKLADREKRAAEQQRKKMEKEAQRLMKKEQNKIGVKLS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O00559 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S36 | Phosphorylation | Uniprot | |
| T41 | Phosphorylation | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| Y94 | Phosphorylation | Uniprot | |
| T99 | Phosphorylation | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| K202 | Acetylation | Uniprot |
研究背景
May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
Golgi apparatus membrane>Single-pass type III membrane protein.
Note: According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.
Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
Homodimer.
The coiled coil domain is necessary for the homodimerization.
研究领域
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
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