| 产品: | TNFRSF14 抗体 |
| 货号: | DF6724 |
| 描述: | Rabbit polyclonal antibody to TNFRSF14 |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 分子量: | 30kDa; 30kD(Calculated). |
| 蛋白号: | Q92956 |
| RRID: | AB_2838686 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6724, RRID:AB_2838686.
展开/折叠
HVEML; ATAR; CD270; CD40 like protein precursor; Herpes virus entry mediator A; Herpesvirus entry mediator A; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HveA; HVEM; HVEM L; LIGHT; LIGHTR; TNFRSF14; TNFSF 14; TNR14_HUMAN; TR2; Tumor necrosis factor receptor like gene2; Tumor necrosis factor receptor superfamily member 14; Tumor necrosis factor receptor superfamily member 14 precursor; Tumor necrosis factor receptor-like 2;
抗原和靶标
Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044).
- Q92956 TNR14_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAPALPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVWWFLSGSLVIVIVCSTVGLIICVKRRKPRGDVVKVIVSVQRKRQEAEGEATVIEALQAPPDVTTVAVEETIPSFTGRSPNH
翻译修饰 - Q92956 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N110 | N-Glycosylation | Uniprot | |
| Y141 | Phosphorylation | Uniprot | |
| S240 | Phosphorylation | Uniprot |
研究背景
Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity).
(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.
(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
N-glycosylated.
Cell membrane>Single-pass type I membrane protein.
Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes. Expressed in naive T cells.
Interacts with TRAF2, TRAF3 and TRAF5. Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct. Interacts with LTA and TNFSF14. Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions.
(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D.
(Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.
The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA.
Belongs to the tumor necrosis factor receptor superfamily.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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