产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6775, RRID:AB_2838737.
展开/折叠
ADH 3; ADH5; ADHX; ADHX_HUMAN; Alcohol dehydrogenase (class III) chi polypeptide; alcohol dehydrogenase 5 (class III) chi polypeptide; Alcohol dehydrogenase 5; Alcohol dehydrogenase class 3; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class III; Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; class III alcohol dehydrogenase 5 chi subunit; FALDH; FDH; formaldehyde dehydrogenase; Glutathione dependent formaldehyde dehydrogenase; Glutathione-dependent formaldehyde dehydrogenase; GSH-FDH; GSNOR; hydroxymethyllutathione dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase;
抗原和靶标
- P11766 ADHX_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P11766 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
A2 | Acetylation | Uniprot | |
K7 | Ubiquitination | Uniprot | |
K9 | Ubiquitination | Uniprot | |
K18 | Ubiquitination | Uniprot | |
S21 | Phosphorylation | Uniprot | |
K31 | Ubiquitination | Uniprot | |
K84 | Ubiquitination | Uniprot | |
K101 | Acetylation | Uniprot | |
K101 | Ubiquitination | Uniprot | |
K107 | Acetylation | Uniprot | |
K107 | Ubiquitination | Uniprot | |
K113 | Ubiquitination | Uniprot | |
K120 | Ubiquitination | Uniprot | |
T127 | Phosphorylation | Uniprot | |
S128 | Phosphorylation | Uniprot | |
T131 | Phosphorylation | Uniprot | |
K226 | Acetylation | Uniprot | |
K226 | Ubiquitination | Uniprot | |
K228 | Acetylation | Uniprot | |
K228 | Ubiquitination | Uniprot | |
K233 | Ubiquitination | Uniprot | |
S247 | Phosphorylation | Uniprot | |
T303 | Phosphorylation | Uniprot | |
K315 | Acetylation | Uniprot | |
K315 | Ubiquitination | Uniprot | |
K323 | Ubiquitination | Uniprot | |
S324 | Phosphorylation | Uniprot | |
K330 | Ubiquitination | Uniprot | |
K338 | Acetylation | Uniprot | |
K338 | Ubiquitination | Uniprot | |
K341 | Ubiquitination | Uniprot | |
T347 | Phosphorylation | Uniprot | |
S351 | Phosphorylation | Uniprot | |
K357 | Ubiquitination | Uniprot | |
K366 | Acetylation | Uniprot | |
K366 | Ubiquitination | Uniprot |
研究背景
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol.
Cytoplasm.
Homodimer.
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
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