(1)
(3)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6826, RRID:AB_2838786.
展开/折叠
5''-cyclic nucleotide phosphodiesterase 1B; 63 kDa Cam PDE; 63 kDa Cam-PDE; Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B; Calcium/calmodulin stimulated cyclic nucleotide phosphodiesterase; Calcium/calmodulin-dependent 3''; Calmodulin stimulated phosphodiesterase PDE1B1; Cam PDE 1B; Cam PDE1B; Cam-PDE 1B; PDE 1B; PDE1B; PDE1B_HUMAN; PDE1B1; PDES 1B; PDES1B; Phosphodiesterase 1B; Phosphodiesterase 1B calmodulin dependent; Presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B;
抗原和靶标
- Q01064 PDE1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q01064 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| C17 | S-Nitrosylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| Y62 | Phosphorylation | Uniprot | |
| Y71 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| T375 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot |
研究背景
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Cytoplasm.
Homodimer.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Sensory system > Taste transduction.
· Organismal Systems > Endocrine system > Renin secretion.
文献引用
Application: IHC Species: Human Sample: tumor tissues
限制条款
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