RIPK2 Antibody - #DF6967

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产品: RIPK2 抗体
货号: DF6967
描述: Rabbit polyclonal antibody to RIPK2
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: O43353
RRID: AB_2838923

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
RIPK2 Antibody detects endogenous levels of total RIPK2.
RRID:
AB_2838923
引用格式: Affinity Biosciences Cat# DF6967, RRID:AB_2838923.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CARD 3; CARD carrying kinase; CARD containing ICE associated kinase; CARD containing IL 1 beta ICE kinase; CARD containing IL1 beta ICE kinase; CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase; CARD containing interleukin 1 beta converting enzyme associated kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; CLARP kinase; GIG 30; GIG30; Growth inhibiting gene 30; Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase; Receptor interacting protein 2; Receptor interacting serine threonine kinase 2; Receptor interacting serine/threonine protein kinase 2; Receptor-interacting protein 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP 2; RIP like interacting CLARP kinase; RIP-2; RIP-like-interacting CLARP kinase; RIPK 2; Ripk2; RIPK2_HUMAN; TNFRSF; Tyrosine-protein kinase RIPK2; UNQ277/PRO314/PRO34092;

抗原和靶标

免疫原:

A synthesized peptide derived from human RIPK2, corresponding to a region within N-terminal amino acids.

基因/基因ID:
RIPK2(8767)
描述:
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.

研究领域

· Human Diseases > Infectious diseases: Bacterial > Shigellosis.

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

文献引用

1). Activation of NOD1 on tumor-associated macrophages augments CD8+ T cell-mediated antitumor immunity in hepatocellular carcinoma. Science advances, 2024 (PubMed: 39356756) [IF=11.7]
2). RIPK2 and lysosomal pathway: Unveiling a new mechanism for lung cancer metastasis. Translational oncology, 2025 (PubMed: 39515087) [IF=4.5]

Application: WB    Species: Human    Sample:

Fig. 1. Elevated expression of RIPK2 in lung cancer patients. A. Analysis of RIPK2 expression levels in normal tissues and LUAD tissues in the TCGA database. B. Kaplan–Meier survival analysis of RIPK2 in LUAD patients in the TCGA database. C. Correlation analysis between RIPK2 expression and tumor stemness. D. Correlation analysis between RIPK2 expression and lung cancer T stage, M stage, and overall stage. E. Correlation analysis between RIPK2 expression and immune infiltration in lung cancer. F. Immunohistochemistry analysis of LAMP2 protein expression levels in normal tissues and LUAD tissues. Data sourced from the Human Protein Atlas database. G. Immunohistochemistry was used to detect the location and level of RIPK2 protein expression in normal and LUAD tissues. H. qRT-PCR was employed to assess the endogenous expression levels of RIPK2 in various NSCLC cell lines. I. Western blot analysis was utilized to evaluate the endogenous expression levels of RIPK2 in several NSCLC cell lines. Error bars represent mean ± SD, ***P < 0.001, ** P < 0.01, *P < 0.05.

Application: IHC    Species: Human    Sample:

Fig. 1. Elevated expression of RIPK2 in lung cancer patients. A. Analysis of RIPK2 expression levels in normal tissues and LUAD tissues in the TCGA database. B. Kaplan–Meier survival analysis of RIPK2 in LUAD patients in the TCGA database. C. Correlation analysis between RIPK2 expression and tumor stemness. D. Correlation analysis between RIPK2 expression and lung cancer T stage, M stage, and overall stage. E. Correlation analysis between RIPK2 expression and immune infiltration in lung cancer. F. Immunohistochemistry analysis of LAMP2 protein expression levels in normal tissues and LUAD tissues. Data sourced from the Human Protein Atlas database. G. Immunohistochemistry was used to detect the location and level of RIPK2 protein expression in normal and LUAD tissues. H. qRT-PCR was employed to assess the endogenous expression levels of RIPK2 in various NSCLC cell lines. I. Western blot analysis was utilized to evaluate the endogenous expression levels of RIPK2 in several NSCLC cell lines. Error bars represent mean ± SD, ***P < 0.001, ** P < 0.01, *P < 0.05.

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