| 产品: | NUP62 抗体 |
| 货号: | DF6968 |
| 描述: | Rabbit polyclonal antibody to NUP62 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 53kDa; 53kD(Calculated). |
| 蛋白号: | P37198 |
| RRID: | AB_2838924 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6968, RRID:AB_2838924.
展开/折叠
62 kDa nucleoporin; DKFZp547L134; FLJ20822; FLJ43869; IBSN; MGC841; Nuclear pore glycoprotein p62; nucleoporin 62kDa; Nucleoporin Nup62; nucleoporin p62; nucleoporin p62KD; NUP62; NUP62 protein; p62; SNDI;
抗原和靶标
- P37198 NUP62_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSNLTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSFTGGSTAQPSGFNIGSAGNSAQPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTGPSLFASIATAPTSSATTGLSLCTPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAATATATTTSSSSTTGFALNLKPLAPAGIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNTSGAPADTSDPLQQICKILNAHMDSLQWIDQNSALLQRKVEEVTKVCEGRRKEQERSFRITFD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P37198 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| T281 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| Y434 | Phosphorylation | Uniprot | |
| K435 | Ubiquitination | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| K476 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| T520 | Phosphorylation | Uniprot |
研究背景
Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.
The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
Nucleus>Nuclear pore complex. Cytoplasm>Cytoskeleton>Spindle pole. Nucleus envelope. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Note: Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630).
Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58 (By similarity). Interacts with NUP88. Interacts with NUTF2 (By similarity). Interacts with HIKESHI. Interacts with OSBPL8. Interacts with CAPG. Interacts with SAS6 and TUBG1 at the centrosome. Interacts with MCM3AP isoform GANP.
(Microbial infection) Interacts with Epstein-barr virus BGLF4; this interaction allows BGLF4 nuclear entry.
Contains FG repeats.
Belongs to the nucleoporin NSP1/NUP62 family.
研究领域
· Genetic Information Processing > Translation > RNA transport.
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