产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6982, RRID:AB_2838938.
展开/折叠
EC 2.1.1.8; Histamine N methyltransferase; Histamine N-methyltransferase; HMT; HNMT; HNMT S1; HNMT S2; HNMT_HUMAN;
抗原和靶标
- P50135 HNMT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50135 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S10 | Phosphorylation | Uniprot | |
S52 | Phosphorylation | Uniprot | |
K99 | Ubiquitination | Uniprot | |
K104 | Ubiquitination | Uniprot | |
K130 | Ubiquitination | Uniprot | |
K131 | Ubiquitination | Uniprot | |
T164 | Phosphorylation | Uniprot | |
S174 | Phosphorylation | Uniprot | |
S176 | Phosphorylation | Uniprot | |
S177 | Phosphorylation | Uniprot | |
T284 | Phosphorylation | Uniprot |
研究背景
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Cytoplasm.
Monomer.
Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
研究领域
· Metabolism > Amino acid metabolism > Histidine metabolism.
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