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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6992, RRID:AB_2838948.
展开/折叠
BMPG; Bone marrow proteoglycan; EMBP; Eosinophil granule major basic protein; Eosinophil major basic protein; MBP; MBP1; MGC14537; Natural killer cell activator; Pregnancy associated major basic protein; Pregnancy-associated major basic protein; PRG 2; PRG2; PRG2_HUMAN; Proteoglycan 2; Proteoglycan 2 bone marrow; Proteoglycan 2 preproprotein; Proteoglycan2;
抗原和靶标
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
- P13727 PRG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
翻译修饰 - P13727 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T23 | O-Glycosylation | Uniprot | |
| S24 | O-Glycosylation | Uniprot | |
| T25 | O-Glycosylation | Uniprot | |
| T34 | O-Glycosylation | Uniprot | |
| S62 | O-Glycosylation | Uniprot | |
| N86 | N-Glycosylation | Uniprot |
研究背景
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Nitrated.
Secreted.
Note: The proform is secreted.
Cytoplasmic vesicle>Secretory vesicle.
Note: The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
研究领域
· Human Diseases > Immune diseases > Asthma.
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