产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7044, RRID:AB_2839000.
展开/折叠
AL4A1_HUMAN; aldehyde dehydrogenase 4; aldehyde dehydrogenase 4 family, member A1; Aldehyde dehydrogenase family 4 member A1; Aldehyde dehydrogenase, family 4, subfamily A, member 1; ALDH4; aldh4a1; Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial; Delta-1-pyrroline-5-carboxylate dehydrogenase; L-glutamate gamma-semialdehyde dehydrogenase; mitochondrial; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C dehydrogenase; P5CD; P5CDh; P5CDhL; P5CDhS; Pyrroline-5-carboxylate dehydrogenase; RP11 128M10.1;
抗原和靶标
Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
- P30038 AL4A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P30038 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S44 | Phosphorylation | Uniprot | |
| K93 | Acetylation | Uniprot | |
| Y96 | Phosphorylation | Uniprot | |
| K153 | Methylation | Uniprot | |
| R304 | Methylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| K462 | Acetylation | Uniprot | |
| K495 | Methylation | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| R498 | Methylation | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| T528 | Phosphorylation | Uniprot | |
| K552 | Acetylation | Uniprot |
研究背景
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Mitochondrion matrix.
Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
Homodimer.
Belongs to the aldehyde dehydrogenase family.
研究领域
· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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