(1)
(4)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7130, RRID:AB_2839084.
展开/折叠
AFBP; Alpha pregnancy associated endometrial globulin; Amniotic fluid binding protein; Binding protein 25; Binding protein 26; Binding protein 28; Growth hormone independent binding protein; hIGFBP 1; hIGFBP1; IBP 1; IBP-1; IBP1; IBP1_HUMAN; IGF binding protein 1; IGF BP25; IGF-binding protein 1; IGFBP 1; IGFBP-1; IGFBP1; Insulin like growth factor binding protein 1; Insulin-like growth factor-binding protein 1; Placental protein 12; PP 12; PP12;
抗原和靶标
- P08833 IBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08833 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S45 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | P68400 (CSNK2A1) , P17252 (PRKCA) | Uniprot |
| T127 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | P68400 (CSNK2A1) , P17252 (PRKCA) | Uniprot |
| S156 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| Y158 | Phosphorylation | Uniprot | |
| Y181 | Phosphorylation | Uniprot | |
| T193 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | P68400 (CSNK2A1) , P17252 (PRKCA) | Uniprot |
| S199 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot |
研究背景
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
Secreted.
Binds equally well IGF1 and IGF2.
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