| 产品: | TPM2 抗体 |
| 货号: | DF7183 |
| 描述: | Rabbit polyclonal antibody to TPM2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Sheep, Rabbit, Chicken, Xenopus |
| 分子量: | 33kD; 33kD(Calculated). |
| 蛋白号: | P07951 |
| RRID: | AB_2839135 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7183, RRID:AB_2839135.
展开/折叠
Alpha tropomyosin; AMCD1; Arthrogryposis multiplex congenital distal type 1; Beta tropomyosin; Beta-tropomyosin; Cytoskeletal tropomyosin TM30; DA1; DA2B; epididymis secretory protein Li 273; FLJ41118; Heat stable cytoskeletal protein 30 kDa; HEL-S-273; hscp30; HTM alpha; hTM5; MGC14582; MGC3261; MGC72094; NEM1; NEM4; Nemaline myopathy type 4; OK/SW cl.5; Sarcomeric tropomyosin kappa; TM 5; TM3; TM30; TM30nm; TMSA; TMSB; TPM 1; TPM 3; TPM1 alpha; TPM1 kappa; TPM2; TPM2_HUMAN; TRK; Tropomyosin 1 alpha; Tropomyosin 1 alpha chain; Tropomyosin 1 alpha chain isoform 6; Tropomyosin 2 (beta); Tropomyosin 2; Tropomyosin 3; Tropomyosin alpha 3 chain; Tropomyosin alpha striated muscle isoform; Tropomyosin beta chain; Tropomyosin gamma; Tropomyosin skeletal muscle beta; Tropomyosin-2;
抗原和靶标
- P07951 TPM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P07951 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K12 | Acetylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| K29 | Acetylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| K48 | Acetylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| T53 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K76 | Acetylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| T108 | Phosphorylation | Uniprot | |
| K112 | Acetylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K118 | Acetylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| K128 | Sumoylation | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| K140 | Acetylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| Y162 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K220 | Acetylation | Uniprot | |
| K220 | Methylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| T237 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| K248 | Acetylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| Y261 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot |
研究背景
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).
Cytoplasm>Cytoskeleton.
Note: Associates with F-actin stress fibers.
Present in primary breast cancer tissue, absent from normal breast tissue.
Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Belongs to the tropomyosin family.
研究领域
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
限制条款
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