产品: | SUMO4 抗体 |
货号: | DF7186 |
描述: | Rabbit polyclonal antibody to SUMO4 |
应用: | WB IHC |
反应: | Human, Mouse, Rat, Monkey |
分子量: | 12kDa; 11kD(Calculated). |
蛋白号: | Q6EEV6 |
RRID: | AB_2839138 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7186, RRID:AB_2839138.
展开/折叠
dJ281H8.4; IDDM5; Small ubiquitin like modifier 4 protein; Small ubiquitin-like protein 4; Small ubiquitin-related modifier 4; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae); SMT3H4; SUMO 4; SUMO-4; SUMO4; SUMO4_HUMAN;
抗原和靶标
Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
- Q6EEV6 SUMO4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSMKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY
翻译修饰 - Q6EEV6 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K11 | Sumoylation | Uniprot | |
K21 | Ubiquitination | Uniprot | |
S28 | Phosphorylation | Uniprot | |
K33 | Acetylation | Uniprot | |
K33 | Methylation | Uniprot | |
K33 | Sumoylation | Uniprot | |
K33 | Ubiquitination | Uniprot | |
K35 | Ubiquitination | Uniprot |
研究背景
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.
Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
Interacts with SAE2. Covalently attached to a number of proteins (Probable).
Belongs to the ubiquitin family. SUMO subfamily.
研究领域
· Genetic Information Processing > Translation > RNA transport.
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