| 产品: | PACAP receptor 抗体 |
| 货号: | DF7197 |
| 描述: | Rabbit polyclonal antibody to PACAP receptor |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 53kDa; 53kD(Calculated). |
| 蛋白号: | P41586 |
| RRID: | AB_2839149 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7197, RRID:AB_2839149.
展开/折叠
ADCYAP1 R1; ADCYAP1R 1; ADCYAP1R1; Adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1; Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; PAC 1; PAC1; PAC1R; PACAP receptor 1; PACAP type I receptor; PACAP-R-1; PACAP-R1; PACAP1 R; PACAPR; PACAPRI; PACR_HUMAN; Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; Pituitary adenylate cyclase activating polypeptide receptor; Pituitary adenylate cyclase activating polypeptide type I receptor precursor; Pituitary adenylate cyclase-activating polypeptide 1, receptor for; Pituitary adenylate cyclase-activating polypeptide type I receptor; pvr1;
抗原和靶标
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
- P41586 PACR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P41586 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S216 | Phosphorylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| T468 | Phosphorylation | Uniprot |
研究背景
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Cell membrane>Multi-pass membrane protein.
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Interacts (via N-terminal extracellular domain) with ADCYAP1.
Belongs to the G-protein coupled receptor 2 family.
研究领域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Renin secretion.
限制条款
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