产品描述
来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC: 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
反应:
Human,Mouse,Rat
预测:
Pig(91%), Bovine(91%), Sheep(82%), Dog(91%)
克隆:
Polyclonal
特异性:
Annexin A6 Antibody detects endogenous levels of total Annexin A6.
RRID:
AB_2833266
引用格式: Affinity Biosciences Cat# AF0116, RRID:AB_2833266.
引用格式: Affinity Biosciences Cat# AF0116, RRID:AB_2833266.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:
展开/折叠
67 kDa calelectrin; Annexin A6; Annexin VI; Annexin VI p68; Annexin-6; AnnexinA6; AnnexinVI; ANX 6; ANX A6; ANX6; ANXA 6; ANXA6; ANXA6_HUMAN; Calcium binding protein p68; Calelectrin; Calphobindin II; Calphobindin-II; CalphobindinII; CBP 68; CBP68; Chromobindin 20; Chromobindin-20; Chromobindin20; CPB II; CPB-II; CPBII; Lipocortin VI; LipocortinVI; p68; p70; Protein III; ProteinIII;
抗原和靶标
免疫原:
Uniprot:
基因/基因ID:
描述:
ANXA6 a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
序列:
- P08133 ANXA6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCGGED
种属预测
种属预测:
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
Species
Results
Score
Pig
91
Bovine
91
Dog
91
Sheep
82
Xenopus
73
Chicken
64
Horse
57
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08133 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| K9 | Acetylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| Y10 | Phosphorylation | Uniprot | |
| R11 | Methylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| Y30 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| K40 | Acetylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K68 | Acetylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| K75 | Acetylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K81 | Acetylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| Y95 | Phosphorylation | Uniprot | |
| K99 | Acetylation | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| K102 | Acetylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| C114 | S-Nitrosylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| Y185 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| R259 | Methylation | Uniprot | |
| K265 | Acetylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| T273 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| Y302 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| K306 | Acetylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| K314 | Acetylation | Uniprot | |
| Y340 | Phosphorylation | Uniprot | |
| T356 | Phosphorylation | Uniprot | |
| K370 | Acetylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| T381 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| K418 | Acetylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| K442 | Acetylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K456 | Ubiquitination | Uniprot | |
| T464 | Phosphorylation | Uniprot | |
| K478 | Acetylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| K483 | Acetylation | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| T535 | Phosphorylation | Uniprot | |
| S537 | Phosphorylation | Uniprot | |
| K540 | Ubiquitination | Uniprot | |
| K568 | Ubiquitination | Uniprot | |
| Y572 | Phosphorylation | Uniprot | |
| K579 | Ubiquitination | Uniprot | |
| K580 | Acetylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| K600 | Ubiquitination | Uniprot | |
| K607 | Acetylation | Uniprot | |
| K607 | Ubiquitination | Uniprot | |
| Y609 | Phosphorylation | Uniprot | |
| K613 | Acetylation | Uniprot | |
| K620 | Acetylation | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| S630 | Phosphorylation | Uniprot | |
| K644 | Ubiquitination | Uniprot | |
| K647 | Acetylation | Uniprot | |
| K647 | Ubiquitination | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| K663 | Ubiquitination | Uniprot |
研究背景
功能:
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
翻译修饰:
Phosphorylated in response to growth factor stimulation.
细胞定位:
Cytoplasm. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
蛋白家族:
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Belongs to the annexin family.
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