(2)
(5)
| 产品: | RRM2 抗体 |
| 货号: | DF7248 |
| 描述: | Rabbit polyclonal antibody to RRM2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Chicken |
| 分子量: | 45kDa; 45kD(Calculated). |
| 蛋白号: | P31350 |
| RRID: | AB_2839187 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7248, RRID:AB_2839187.
展开/折叠
cb111; chunp6884; etID309896.20; R2; reductase M2 polypeptide variant 1; reductase M2 polypeptide variant 2; reductase M2 polypeptide variant 3a; reductase M2 polypeptide variant 3b; reductase M2 polypeptide variant 3c; reductase M2 polypeptide variant 3d; Ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase M2; Ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase M2 subunit; ribonucleotide reductase protein r2 class I; Ribonucleotide reductase regulatory subunit M2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; Ribonucleotide reductase, R2 subunit; RIR2_HUMAN; RR2; RR2M; RRM2;
抗原和靶标
- P31350 RIR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P31350 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T12 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | P06493 (CDK1) , P24941 (CDK2) | Uniprot |
| K23 | Ubiquitination | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| T33 | Phosphorylation | P06493 (CDK1) , P24941 (CDK2) | Uniprot |
| S38 | Phosphorylation | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| T56 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| R212 | Methylation | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| T318 | Phosphorylation | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| K364 | Acetylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot |
研究背景
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.
Cytoplasm.
Heterodimer of a large and a small subunit.
Belongs to the ribonucleoside diphosphate reductase small chain family.
研究领域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
文献引用
Application: WB Species: human Sample:
Application: WB Species: Human Sample: breast cancer tissue
限制条款
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