产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7260, RRID:AB_2839199.
展开/折叠
Adenosylhomocysteinase; AdoHcyase; ahcY; S adenosyl L homocysteine hydrolase; S adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase; SAHH; SAHH_HUMAN;
抗原和靶标
- P23526 SAHH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P23526 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| K4 | Acetylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| K8 | Methylation | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| R34 | Methylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| Y100 | Phosphorylation | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| Y143 | Phosphorylation | Uniprot | |
| R151 | Methylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K188 | Acetylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| C195 | S-Nitrosylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| R233 | Methylation | Uniprot | |
| K291 | Methylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| K322 | Sumoylation | Uniprot | |
| K322 | Ubiquitination | Uniprot | |
| Y379 | Phosphorylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K401 | Acetylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K408 | Acetylation | Uniprot | |
| K408 | Ubiquitination | Uniprot | |
| T410 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y416 | Phosphorylation | Uniprot | |
| S420 | Phosphorylation | Uniprot | |
| C421 | S-Nitrosylation | Uniprot | |
| K426 | Acetylation | Uniprot | |
| Y430 | Phosphorylation | Uniprot | |
| R431 | Methylation | Uniprot |
研究背景
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Cytoplasm. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Homotetramer.
Belongs to the adenosylhomocysteinase family.
研究领域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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