NDRG2 Antibody - #DF7272

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产品: NDRG2 抗体
货号: DF7272
描述: Rabbit polyclonal antibody to NDRG2
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 41kDa; 41kD(Calculated).
蛋白号: Q9UN36
RRID: AB_2839211

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
NDRG2 Antibody detects endogenous levels of total NDRG2.
RRID:
AB_2839211
引用格式: Affinity Biosciences Cat# DF7272, RRID:AB_2839211.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Antidepressant related protein ADRG123; Cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N myc downstream regulated gene 2; N myc downstream regulator 2; NDR1 related protein NDR2; NDRG 2; NDRG family member 2; NDRG1 related protein; NDRG2; NDRG2_HUMAN; Protein NDRG2; Protein Syld709613; SYLD; Syld709613 protein;

抗原和靶标

免疫原:
Uniprot:

Q9UN36(NDRG2_HUMAN) >>Visit HPA database.

基因/基因ID:
NDRG2(57447)
表达:
Q9UN36 NDRG2_HUMAN:

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

描述:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
序列:
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
100
Rabbit
100
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UN36 作为底物

Site PTM Type Enzyme
A2 Acetylation
T20 Phosphorylation
Y47 Phosphorylation
T57 Phosphorylation
R247 Methylation
S276 Phosphorylation
Y309 Phosphorylation
S319 Phosphorylation
T323 Phosphorylation
S326 Phosphorylation
S328 Phosphorylation
T330 Phosphorylation O00141 (SGK1)
S332 Phosphorylation P23443 (RPS6KB1) , O00141 (SGK1) , P31749 (AKT1) , Q15418 (RPS6KA1)
T334 Phosphorylation
S335 Phosphorylation
S338 Phosphorylation
S344 Phosphorylation
S346 Phosphorylation O00141 (SGK1)
T348 Phosphorylation O00141 (SGK1) , P31749 (AKT1)
S350 Phosphorylation Q15418 (RPS6KA1) , P23443 (RPS6KB1)
S352 Phosphorylation
S353 Phosphorylation
S355 Phosphorylation
T357 Phosphorylation
S359 Phosphorylation
S360 Phosphorylation
T366 Phosphorylation
S370 Phosphorylation

研究背景

功能:

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

细胞定位:

Cytoplasm. Cytoplasm>Perinuclear region. Cell projection>Growth cone.
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

亚基结构:

Interacts with CTNNB1.

蛋白家族:

Belongs to the NDRG family.

文献引用

1). Inhibition of PI3K/Akt/mTOR signaling by NDRG2 contributes to neuronal apoptosis and autophagy in ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023 (PubMed: 36652790) [IF=2.5]

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