IMPDH2 Antibody - #DF7291

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产品: IMPDH2 抗体
货号: DF7291
描述: Rabbit polyclonal antibody to IMPDH2
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Horse, Dog
分子量: 55kDa; 56kD(Calculated).
蛋白号: P12268
RRID: AB_2839230

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
IHC Protocol
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(88%), Horse(88%), Dog(88%)
克隆:
Polyclonal
特异性:
IMPDH2 Antibody detects endogenous levels of total IMPDH2.
RRID:
AB_2839230
引用格式: Affinity Biosciences Cat# DF7291, RRID:AB_2839230.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

IMDH2_HUMAN; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH-II; Impdh2; Inosine 5' monophosphate dehydrogenase 2; Inosine 5' phosphate dehydrogenase 2; Inosine monophosphate dehydrogenase type II; Inosine-5''-monophosphate dehydrogenase 2;

抗原和靶标

免疫原:
Uniprot:

P12268(IMDH2_HUMAN) >>Visit HPA database.

基因/基因ID:
IMPDH2(3615)
表达:
P12268 IMDH2_HUMAN:

IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

描述:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
序列:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
88
Horse
88
Dog
88
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P12268 作为底物

Site PTM Type Enzyme
K109 Ubiquitination
S122 Phosphorylation P24941 (CDK2)
K124 Ubiquitination
K134 Acetylation
K134 Ubiquitination
C140 S-Nitrosylation
S159 Phosphorylation
S160 Phosphorylation
C173 S-Nitrosylation
K181 Ubiquitination
K195 Acetylation
K195 Ubiquitination
R203 Methylation
K205 Ubiquitination
K206 Ubiquitination
K208 Acetylation
K208 Ubiquitination
R231 Methylation
S237 Phosphorylation
K238 Ubiquitination
K242 Ubiquitination
K257 Ubiquitination
K288 Ubiquitination
K291 Ubiquitination
K293 Acetylation
K293 Ubiquitination
K311 Ubiquitination
T345 Phosphorylation
Y348 Phosphorylation
K349 Ubiquitination
K375 Ubiquitination
Y400 Phosphorylation
Y411 Phosphorylation
R412 Methylation
S416 Phosphorylation
K422 Acetylation
K422 Ubiquitination
S425 Phosphorylation
S426 Phosphorylation
R429 Methylation
Y430 Phosphorylation
S432 Phosphorylation
K436 Acetylation
K436 Ubiquitination
K438 Ubiquitination
S444 Phosphorylation
K450 Ubiquitination
K455 Ubiquitination
Y459 Phosphorylation
K474 Ubiquitination
K489 Ubiquitination
S505 Phosphorylation
Y509 Phosphorylation
K511 Acetylation
K511 Ubiquitination

研究背景

功能:

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

翻译修饰:

The N-terminus is blocked.

Acetylated by CLOCK in a circadian manner.

细胞定位:

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

亚基结构:

Homotetramer Ref.25, Ref.26). Interacts with CLOCK; in a circadian manner.

蛋白家族:

Belongs to the IMPDH/GMPR family.

研究领域

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.

· Metabolism > Global and overview maps > Metabolic pathways.

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