| 产品: | VAPB 抗体 |
| 货号: | DF7303 |
| 描述: | Rabbit polyclonal antibody to VAPB |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 27kDa; 27kD(Calculated). |
| 蛋白号: | O95292 |
| RRID: | AB_2839241 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7303, RRID:AB_2839241.
展开/折叠
ALS 8; ALS8; D2Abb2e; UNQ484/PRO983; Vamp 33b; VAMP associated 33 kDa protein; VAMP associated protein B and C; VAMP associated protein B; VAMP associated protein B/C; VAMP associated protein C; VAMP B; VAMP B VAMP C; VAMP B/VAMP C; VAMP C; VAMP vesicle associated membrane protein associated protein B and C; Vamp33b; VAMPB; VAMPB/VAMPC; VAMPC; VAP 33b; VAP B; VAP B/VAP C; VAP C; VAP33b; VAPB/VAPC; VAPC; Vesicle associated membrane protein associated protein B and C; Vesicle associated membrane protein associated protein B/C;
抗原和靶标
- O95292 VAPB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL
翻译修饰 - O95292 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| T27 | Phosphorylation | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| R38 | Methylation | Uniprot | |
| K43 | Methylation | Uniprot | |
| K118 | Acetylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| K147 | Acetylation | Uniprot | |
| K147 | Sumoylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| K216 | Acetylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot |
研究背景
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Endoplasmic reticulum membrane>Single-pass type IV membrane protein.
Note: Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.
Ubiquitous. Isoform 1 predominates.
Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27. Interacts with RMDN3. Interacts with KIF5A in a ZFYVE27-dependent manner. Interacts with STARD3 (via FFAT motif). Interacts with STARD3NL (via FFAT motif). Interacts with CERT1.
(Microbial infection) Interacts with HCV protein NS5A and NS5B.
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
研究领域
· Organismal Systems > Digestive system > Cholesterol metabolism.
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