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| 产品: | PVRL2 抗体 |
| 货号: | DF7313 |
| 描述: | Rabbit polyclonal antibody to PVRL2 |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 57kDa; 58kD(Calculated). |
| 蛋白号: | Q92692 |
| RRID: | AB_2839251 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7313, RRID:AB_2839251.
展开/折叠
CD 112; CD112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Nectin-2; Nectin2; Poliovirus receptor like 2; Poliovirus receptor related 2 (herpesvirus entry mediator B); Poliovirus receptor related 2; Poliovirus receptor related protein 2; Poliovirus receptor-related protein 2; PRR 2; PRR2; PVRL 2; PVRL2; PVRL2_HUMAN; PVRR 2; PVRR2;
抗原和靶标
- Q92692 NECT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92692 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| S95 | O-Glycosylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| T172 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| T352 | Phosphorylation | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| T410 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| Y454 | Phosphorylation | Uniprot | |
| T459 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| Y513 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| Y518 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| Y537 | Phosphorylation | Uniprot |
研究背景
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Cell membrane>Single-pass type I membrane protein.
Ubiquitous.
Can form trans-heterodimers with NECTIN3 (By similarity). Interacts with CD226 or with PVRIG; these interactions are competitive and have a differential functional outcome on T-cell activation, either positive or negative, respectively. Binds with low affinity to TIGIT.
(Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D.
Belongs to the nectin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
文献引用
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