产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7320, RRID:AB_2839258.
展开/折叠
BFD; CFP; Complement factor P; Complement factor properdin; Factor P; PFC; PFD; PROP_HUMAN; Properdin; Properdin P factor complement;
抗原和靶标
- P27918 PROP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P27918 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| W83 | C-Glycosylation | Uniprot | |
| W86 | C-Glycosylation | Uniprot | |
| T92 | O-Glycosylation | Uniprot | |
| W139 | C-Glycosylation | Uniprot | |
| W142 | C-Glycosylation | Uniprot | |
| W145 | C-Glycosylation | Uniprot | |
| T151 | O-Glycosylation | Uniprot | |
| W196 | C-Glycosylation | Uniprot | |
| W199 | C-Glycosylation | Uniprot | |
| S208 | O-Glycosylation | Uniprot | |
| W260 | C-Glycosylation | Uniprot | |
| W263 | C-Glycosylation | Uniprot | |
| T272 | O-Glycosylation | Uniprot | |
| W321 | C-Glycosylation | Uniprot | |
| W324 | C-Glycosylation | Uniprot | |
| W382 | C-Glycosylation | Uniprot | |
| W385 | C-Glycosylation | Uniprot | |
| W388 | C-Glycosylation | Uniprot | |
| N428 | N-Glycosylation | Uniprot |
研究背景
A positive regulator of the alternate pathway (AP) of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
Secreted.
In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20. Interacts with the pro-C3-convertase enzyme complex (C3b-Bb) comprised of Complement C3 beta chain (C3b) and the Complement factor B Bb fragment (Bb), where it binds (via its TSP type-1 5 domain) with C3b and Bb. This interaction stabilizes the complex and allows it to become the active C3-convertase enzyme complex (C3b-Bb-FP). Interacts with C3b. Interacts with CFB.
TSP type-1 domain 0 binds to TSP type-1 domain 4, and TSP type-1 domain 1 binds to TSP type-1 domain 6 (PubMed:15491616, PubMed:28264884, PubMed:31507604). These interactions mediate multimerization (PubMed:15491616, PubMed:28264884, PubMed:31507604).
研究领域
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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