SERPINB3 Antibody - #DF7335

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产品: SERPINB3 抗体
货号: DF7335
描述: Rabbit polyclonal antibody to SERPINB3
应用: WB IHC
反应: Human, Rat
分子量: 44kDa; 45kD(Calculated).
蛋白号: P29508
RRID: AB_2839273

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
IHC Protocol
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
克隆:
Polyclonal
特异性:
SERPINB3 Antibody detects endogenous levels of total SERPINB3.
RRID:
AB_2839273
引用格式: Affinity Biosciences Cat# DF7335, RRID:AB_2839273.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HsT1196; Protein T4 A; Protein T4-A; SCC; SCCA; SCCA PD; SCCA-1; SCCA-PD; SCCA1; SCCAPD; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3; Serpin B3; Serpin peptidase inhibitor clade B (ovalbumin) member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; SERPINB3; SPB3_HUMAN; Squamous cell carcinoma antigen 1; T4 A; T4-A; T4A;

抗原和靶标

免疫原:
Uniprot:

P29508(SPB3_HUMAN) >>Visit HPA database.

基因/基因ID:
SERPINB3(6317)
表达:
P29508 SPB3_HUMAN:

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

序列:
MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP

翻译修饰 - P29508 作为底物

Site PTM Type Enzyme
T35 Phosphorylation
Y73 Phosphorylation
Y119 Phosphorylation
T129 Phosphorylation
S149 Phosphorylation
S153 Phosphorylation
Y181 Phosphorylation
T206 Phosphorylation
K208 Acetylation
Y216 Phosphorylation
Y384 Phosphorylation

研究背景

功能:

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

细胞定位:

Cytoplasm.
Note: Seems to also be secreted in plasma by cancerous cells but at a low level.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

亚基结构:

Interacts with MAPK8/JNK1.

蛋白家族:

Belongs to the serpin family. Ov-serpin subfamily.

研究领域

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

文献引用

1). A novel signature constructed by mitochondrial function and cell death-related gene for the prediction of prognosis in bladder cancer. Scientific reports, 2024 (PubMed: 38918587) [IF=4.6]

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