GDI1 Antibody - #DF7352

(2)  
产品: GDI1 抗体
货号: DF7352
描述: Rabbit polyclonal antibody to GDI1
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 55kDa; 51kD(Calculated).
蛋白号: P31150
RRID: AB_2839290

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
GDI1 Antibody detects endogenous levels of total GDI1.
RRID:
AB_2839290
引用格式: Affinity Biosciences Cat# DF7352, RRID:AB_2839290.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

1A; FLJ41411; GDI-1; gdi1; GDIA_HUMAN; GDIL; GDP dissociation inhibitor 1; Guanosine diphosphate dissociation inhibitor 1; Mental retardation X-linked 41; Mental retardation X-linked 48; MRX41; MRX48; Oligophrenin 2; Oligophrenin-2; OPHN2; Protein XAP 4; Protein XAP-4; Protein XAP4; Rab GDI alpha; Rab GDP dissociation inhibitor alpha; RABGD1A; RABGDIA; XAP 4;

抗原和靶标

免疫原:
Uniprot:

P31150(GDIA_HUMAN) >>Visit HPA database.

基因/基因ID:
GDI1(2664)
表达:
P31150 GDIA_HUMAN:

Brain; predominant in neural and sensory tissues.

描述:
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation.
序列:
MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
100
Rabbit
100
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P31150 作为底物

Site PTM Type Enzyme
K29 Ubiquitination
R35 Methylation
Y38 Phosphorylation
S43 Phosphorylation
S45 Phosphorylation
K54 Ubiquitination
S65 Phosphorylation
R68 Methylation
R70 Methylation
K79 Ubiquitination
Y93 Phosphorylation
T94 Phosphorylation
Y99 Phosphorylation
Y111 Phosphorylation
K112 Ubiquitination
Y117 Phosphorylation
K137 Ubiquitination
R169 Methylation
K174 Ubiquitination
K210 Ubiquitination
S215 Phosphorylation
K221 Acetylation
K221 Methylation
K221 Ubiquitination
S222 Phosphorylation
Y224 Phosphorylation
Y226 Phosphorylation
Y229 Phosphorylation
K253 Ubiquitination
K264 Methylation
K269 Acetylation
K269 Ubiquitination
K278 Ubiquitination
R290 Methylation
K309 Ubiquitination
S316 Phosphorylation
C317 S-Nitrosylation
Y333 Phosphorylation
S338 Phosphorylation
Y339 Phosphorylation
Y349 Phosphorylation
T413 Phosphorylation
K435 Ubiquitination
K437 Ubiquitination

研究背景

功能:

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

细胞定位:

Cytoplasm. Golgi apparatus>trans-Golgi network.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Brain; predominant in neural and sensory tissues.

亚基结构:

Interacts with RHOH. Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43.

蛋白家族:

Belongs to the Rab GDI family.

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