KLC1 Antibody - #DF7392

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产品: KLC1 抗体
货号: DF7392
描述: Rabbit polyclonal antibody to KLC1
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Rabbit, Dog, Xenopus
分子量: 65kDa; 65kD(Calculated).
蛋白号: Q07866
RRID: AB_2839330

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
KLC1 Antibody detects endogenous levels of total KLC1.
RRID:
AB_2839330
引用格式: Affinity Biosciences Cat# DF7392, RRID:AB_2839330.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Kinesin 2 60/70kDa; Kinesin light chain 1; Kinesin2; KLC 1; KLC; Klc1; KLC1_HUMAN; KNS 2; KNS 2A; KNS2; KNS2A; Medulloblastoma antigen MU MB 2.50; MGC15245;

抗原和靶标

免疫原:
Uniprot:

Q07866(KLC1_HUMAN) >>Visit HPA database.

基因/基因ID:
KLC1(3831)
表达:
Q07866 KLC1_HUMAN:

Found in a variety of tissues. Mostly abundant in brain and spine.

描述:
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.
序列:
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Bovine
100
Dog
100
Xenopus
100
Rabbit
100
Pig
0
Horse
0
Sheep
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q07866 作为底物

Site PTM Type Enzyme
Y2 Phosphorylation
Y10 Phosphorylation
K18 Ubiquitination
K54 Ubiquitination
S75 Phosphorylation
S134 Phosphorylation
K146 Ubiquitination
S162 Phosphorylation
Y207 Phosphorylation
K237 Ubiquitination
Y271 Phosphorylation
K272 Acetylation
Y307 Phosphorylation
K309 Ubiquitination
Y360 Phosphorylation
Y369 Phosphorylation
T371 Phosphorylation
K372 Ubiquitination
K384 Ubiquitination
S389 Phosphorylation
K393 Acetylation
K393 Ubiquitination
S418 Phosphorylation
K441 Ubiquitination
S445 Phosphorylation
Y449 Phosphorylation
K454 Methylation
S460 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3)
T462 Phosphorylation
T464 Phosphorylation
T465 Phosphorylation
K495 Ubiquitination
K503 Ubiquitination
R505 Methylation
K518 Ubiquitination
S521 Phosphorylation Q13131 (PRKAA1)
S524 Phosphorylation
Y532 Phosphorylation
S557 Phosphorylation

研究背景

功能:

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

细胞定位:

Cell projection>Growth cone. Cytoplasmic vesicle. Cytoplasm>Cytoskeleton.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Found in a variety of tissues. Mostly abundant in brain and spine.

亚基结构:

Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (By similarity). Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with BORCS5. Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (By similarity).

(Microbial infection) Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.

蛋白家族:

Belongs to the kinesin light chain family.

研究领域

· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.

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