| 产品: | TFCP2 抗体 |
| 货号: | DF7395 |
| 描述: | Rabbit polyclonal antibody to TFCP2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 57kDa; 57kD(Calculated). |
| 蛋白号: | Q12800 |
| RRID: | AB_2839333 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7395, RRID:AB_2839333.
展开/折叠
Alpha globin transcription factor CP2; Alpha-globin transcription factor CP2; CP2; Late SV40 factor; LBP 1C; LBP1C; LSF; LSF1D; SAA3 enhancer factor; SEF; TFCP2; TFCP2_HUMAN; TFCP2C; Transcription factor CP2; Transcription factor LSF;
抗原和靶标
Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).
- Q12800 TFCP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDNENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQKHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDEMIQNFQEEACFILDTMKAETNDSYHIILK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q12800 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K50 | Sumoylation | Uniprot | |
| R98 | Methylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| T194 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| T258 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S289 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S291 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) , P24941 (CDK2) | Uniprot |
| S309 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) , Q00526 (CDK3) , P24941 (CDK2) | Uniprot |
| S343 | Phosphorylation | Uniprot | |
| T344 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| K359 | Ubiquitination | Uniprot |
研究背景
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
Nucleus.
Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).
Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.
Belongs to the grh/CP2 family. CP2 subfamily.
限制条款
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