| 产品: | TPP1 抗体 |
| 货号: | DF7425 |
| 描述: | Rabbit polyclonal antibody to TPP1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 61kDa; 61kD(Calculated). |
| 蛋白号: | O14773 |
| RRID: | AB_2839363 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7425, RRID:AB_2839363.
展开/折叠
Cell growth inhibiting gene 1 protein; Cell growth-inhibiting gene 1 protein; Ceroid lipofuscinosis neuronal 2; Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease); Ceroid lipofuscinosis neuronal 2 late infantile; CLN 2; CLN2; GIG 1; GIG1; Growth inhibiting protein 1; LPIC; Lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; MGC21297; TPP 1; TPP I; TPP-1; TPP-I; Tpp1; TPP1_HUMAN; TPPI; Tripeptidyl aminopeptidase; Tripeptidyl peptidase I; Tripeptidyl-peptidase 1; Tripeptidyl-peptidase I;
抗原和靶标
Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
- O14773 TPP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14773 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T201 | Phosphorylation | P06493 (CDK1) | Uniprot |
| N210 | N-Glycosylation | Uniprot | |
| N222 | N-Glycosylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| N286 | N-Glycosylation | Uniprot | |
| N313 | N-Glycosylation | Uniprot | |
| K428 | Sumoylation | Uniprot | |
| N443 | N-Glycosylation | Uniprot | |
| Y459 | Phosphorylation | Uniprot | |
| T478 | Phosphorylation | Uniprot |
研究背景
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity.
Lysosome. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Monomer. Interacts with CLN5.
研究领域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
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