产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7434, RRID:AB_2839372.
展开/折叠
ERGB transcription factor; Ewing Sarcoma breakpoint region 2; EWSR 2; EWSR2; FLI 1; FLI 1 proto oncogene; Fli-1 proto-oncogene, ETS transcription factor; FLI1; FLI1 EWS fusion gene; FLI1 proto oncogene; FLI1_HUMAN; Friend leukemia integration 1 (FLI1) transcription factor; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; Sarcoma breakpoint region 2 (EWSR2); SIC 1; SIC1; Transcription factor ERGB; Viral integration region FLI1; Viral integration region FLI1, mouse, homolog of;
抗原和靶标
- Q01543 FLI1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q01543 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| T35 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| Y42 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| K67 | Sumoylation | Uniprot | |
| Y70 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| Y222 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| K252 | Acetylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Q05655 (PRKCD) | Uniprot |
| K325 | Ubiquitination | Uniprot | |
| Y332 | Phosphorylation | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| K380 | Acetylation | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K397 | Acetylation | Uniprot | |
| R438 | Methylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| Y451 | Phosphorylation | Uniprot | |
| Y452 | Phosphorylation | Uniprot |
研究背景
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Nucleus.
Can form homodimers or heterodimers with ETV6/TEL1.
Belongs to the ETS family.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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