| 产品: | CACNG5 抗体 |
| 货号: | DF2265 |
| 描述: | Rabbit polyclonal antibody to CACNG5 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Bovine, Dog, Chicken, Xenopus |
| 分子量: | 31 kDa; 31kD(Calculated). |
| 蛋白号: | Q9UF02 |
| RRID: | AB_2839494 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2265, RRID:AB_2839494.
展开/折叠
CACNG 5; Cacng5; Calcium channel voltage dependent gamma subunit 5; CCG5_HUMAN; MGC126656; MGC126682; Neuronal voltage gated calcium channel gamma 5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; Voltage dependent calcium channel gamma 5 subunit; Voltage-dependent calcium channel gamma-5 subunit;
抗原和靶标
- Q9UF02 CCG5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSACGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGVIVPQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQFLHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSSSPC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UF02 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y175 | Phosphorylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| T189 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot |
研究背景
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Membrane>Multi-pass membrane protein. Cell junction>Synapse>Postsynaptic density membrane.
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
研究领域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
限制条款
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