| 产品: | CENPI 抗体 |
| 货号: | DF2311 |
| 描述: | Rabbit polyclonal antibody to CENPI |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 87 kDa; 87kD(Calculated). |
| 蛋白号: | Q92674 |
| RRID: | AB_2839535 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2311, RRID:AB_2839535.
展开/折叠
CENP I; centromere protein I; Follicle simulating hormone primary response protein; FSH primary response 1; FSH primary response protein 1; FSH primary response, rat, homolog of, 1; FSHP1; FSHPRH1; interphase centromere complex protein 19; Leucine rich primary response gene 1; Leucine rich primary response protein 1; LRPR1; Mis6;
抗原和靶标
- Q92674 CENPI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQAEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPLKRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELPSQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYLDYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQY
翻译修饰 - Q92674 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T16 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| T420 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| K627 | Ubiquitination | Uniprot | |
| Y637 | Phosphorylation | Uniprot | |
| H642 | Phosphorylation | Uniprot | |
| Y643 | Phosphorylation | Uniprot | |
| K659 | Ubiquitination | Uniprot | |
| K670 | Ubiquitination | Uniprot | |
| T705 | Phosphorylation | Uniprot | |
| S709 | Phosphorylation | Uniprot |
研究背景
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.
Nucleus. Chromosome>Centromere.
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6.
Belongs to the CENP-I/CTF3 family.
限制条款
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