| 产品: | EIF4G2 抗体 |
| 货号: | DF2379 |
| 描述: | Rabbit polyclonal antibody to EIF4G2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 102 kDa; 102kD(Calculated). |
| 蛋白号: | P78344 |
| RRID: | AB_2839587 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2379, RRID:AB_2839587.
展开/折叠
DAP-5; Death associated protein 5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; IF4G2_HUMAN; Nat1; Novel APOBEC-1 target 1; p97; Translation repressor NAT1; Translation repressor NAT1;
抗原和靶标
Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney.
- P78344 IF4G2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P78344 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| R23 | Methylation | Uniprot | |
| K31 | Methylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K41 | Methylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| T42 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| T89 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| Y185 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| K230 | Acetylation | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K233 | Acetylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| R360 | Methylation | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| T385 | Phosphorylation | Uniprot | |
| R393 | Methylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| T397 | Phosphorylation | Uniprot | |
| R400 | Methylation | Uniprot | |
| R402 | Methylation | Uniprot | |
| K431 | Methylation | Uniprot | |
| K431 | Ubiquitination | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| R460 | Methylation | Uniprot | |
| K463 | Methylation | Uniprot | |
| K464 | Methylation | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| R475 | Methylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| R505 | Methylation | Uniprot | |
| T506 | Phosphorylation | Uniprot | |
| T508 | Phosphorylation | Uniprot | |
| T514 | Phosphorylation | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| K529 | Acetylation | Uniprot | |
| K529 | Ubiquitination | Uniprot | |
| K541 | Ubiquitination | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| R592 | Methylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| S605 | Phosphorylation | Uniprot | |
| K640 | Ubiquitination | Uniprot | |
| S641 | Phosphorylation | Uniprot | |
| Y642 | Phosphorylation | Uniprot | |
| R687 | Methylation | Uniprot | |
| K698 | Ubiquitination | Uniprot | |
| K703 | Ubiquitination | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| K732 | Ubiquitination | Uniprot | |
| K735 | Ubiquitination | Uniprot | |
| K739 | Ubiquitination | Uniprot | |
| K742 | Ubiquitination | Uniprot | |
| Y751 | Phosphorylation | Uniprot | |
| K755 | Ubiquitination | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| K761 | Ubiquitination | Uniprot | |
| K806 | Ubiquitination | Uniprot | |
| S811 | Phosphorylation | Uniprot | |
| K813 | Ubiquitination | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| S902 | Phosphorylation | Uniprot |
研究背景
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Phosphorylation; hyperphosphorylated during mitosis.
Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney.
Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD.
Belongs to the eukaryotic initiation factor 4G family.
研究领域
· Genetic Information Processing > Translation > RNA transport.
· Human Diseases > Cardiovascular diseases > Viral myocarditis.
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