XRN1 Antibody - #DF2433

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产品: XRN1 抗体
货号: DF2433
描述: Rabbit polyclonal antibody to XRN1
应用: WB IF/ICC
反应: Human, Mouse
预测: Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 194 kDa; 194kD(Calculated).
蛋白号: Q8IZH2
RRID: AB_2839639

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(82%), Xenopus(100%)
克隆:
Polyclonal
特异性:
XRN1 Antibody detects endogenous levels of total XRN1.
RRID:
AB_2839639
引用格式: Affinity Biosciences Cat# DF2433, RRID:AB_2839639.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

5'-3' exoribonuclease 1; Dhm2; mXRN1; SEP1; Strand-exchange protein 1 homolog;

抗原和靶标

免疫原:
Uniprot:

Q8IZH2(XRN1_HUMAN) >>Visit HPA database.

基因/基因ID:
XRN1(54464)
表达:
Q8IZH2 XRN1_HUMAN:

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.

序列:
MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Chicken
82
Pig
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q8IZH2 作为底物

Site PTM Type Enzyme
K79 Ubiquitination
K118 Ubiquitination
K268 Acetylation
T270 Phosphorylation
Y273 Phosphorylation
K338 Ubiquitination
K342 Ubiquitination
K364 Ubiquitination
K368 Ubiquitination
Y384 Phosphorylation
K391 Ubiquitination
S396 Phosphorylation
K413 Ubiquitination
K572 Ubiquitination
S584 Phosphorylation
K586 Ubiquitination
K618 Ubiquitination
K652 Ubiquitination
K673 Ubiquitination
K736 Ubiquitination
K747 Ubiquitination
T753 Phosphorylation
K758 Ubiquitination
K765 Ubiquitination
K772 Ubiquitination
Y797 Phosphorylation
T802 Phosphorylation
K805 Ubiquitination
K818 Ubiquitination
Y829 Phosphorylation
S844 Phosphorylation
K847 Ubiquitination
K910 Ubiquitination
R939 Methylation
K950 Ubiquitination
K971 Ubiquitination
Y990 Phosphorylation
K1035 Ubiquitination
K1130 Ubiquitination
S1173 Phosphorylation
S1176 Phosphorylation
K1228 Ubiquitination
K1245 Ubiquitination
Y1248 Phosphorylation
K1256 Ubiquitination
K1272 Ubiquitination
S1279 Phosphorylation
K1281 Ubiquitination
Y1282 Phosphorylation
S1299 Phosphorylation
K1301 Ubiquitination
S1306 Phosphorylation
K1308 Ubiquitination
S1348 Phosphorylation
K1364 Acetylation
K1364 Ubiquitination
K1374 Ubiquitination
K1378 Ubiquitination
Y1394 Phosphorylation
S1398 Phosphorylation
K1401 Ubiquitination
K1412 Acetylation
Y1419 Phosphorylation
S1451 Phosphorylation
K1621 Ubiquitination
T1629 Phosphorylation
T1633 Phosphorylation
S1638 Phosphorylation
S1645 Phosphorylation
S1653 Phosphorylation
S1692 Phosphorylation

研究背景

功能:

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

细胞定位:

Cytoplasm.
Note: Discrete foci at the inner surface of the cell membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.

亚基结构:

Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1. Associates with alpha and beta tubulins (By similarity). Interacts with DIS3L2. Interacts with ZC3HAV1 in an RNA-dependent manner. Interacts with ZFP36L1. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner. Interacts with YTHDC2 (via ANK repeats).

蛋白家族:

Belongs to the 5'-3' exonuclease family.

研究领域

· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.

· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.

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