产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2464, RRID:AB_2839670.
展开/折叠
ATL1 alpha; ATL1; ATL1 beta; ATL1 gamma; ATL1-delta; B cell CLL/lymphoma 11B/T cell receptor delta constant region fusion protein; B cell lymphoma/leukemia 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B; B-cell lymphoma/leukemia 11B; BC11B_HUMAN; BCL-11B; Bcl11b; BCL11B/TRDC fusion; COUP TF interacting protein 2; COUP-TF interacting protein 2; COUP-TF-interacting protein 2; Ctip 2; CTIP-2; CTIP2; hRIT1 alpha; hRit1; Radiation induced tumor suppressor gene 1; Radiation induced tumor suppressor gene 1 protein; Radiation-induced tumor suppressor gene 1 protein; Rit 1; Rit1; zinc finger protein hRit1 alpha; ZNF856B;
抗原和靶标
Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
- Q9C0K0 BC11B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRKQGNPQHLSQRELITPEADHVEAAILEEDEGLEIEEPSGLGLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKRKQCGGSLGACYDKALDKDSPPPSSRSELRKVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPAVAPIAASSHPHSSVITSPLRALGALPPCLPLPCCSARPVSGDGTQGEGQTEAPFGCQCQLSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASSSLTPRLTIPPPLGPEAVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPPGGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELAGEGLKAADGDFRHHESDPSLGHEPEEEDEEEEEEEEELLLENESRPESSFSMDSELSRNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKRGAFLKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPSPGLNSAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9C0K0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| T120 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| T131 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| R262 | Methylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S286 | Phosphorylation | Uniprot | |
| R293 | Methylation | Uniprot | |
| R300 | Methylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| R322 | Methylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| T406 | Phosphorylation | Uniprot | |
| T417 | Phosphorylation | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K434 | Acetylation | Uniprot | |
| K434 | Ubiquitination | Uniprot | |
| T450 | Phosphorylation | Uniprot | |
| K456 | Ubiquitination | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| K469 | Ubiquitination | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| T502 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Uniprot | |
| S550 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| K585 | Ubiquitination | Uniprot | |
| K591 | Ubiquitination | Uniprot | |
| K597 | Ubiquitination | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| T662 | Phosphorylation | Uniprot | |
| R671 | Methylation | Uniprot | |
| K672 | Ubiquitination | Uniprot | |
| S678 | Phosphorylation | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| K689 | Ubiquitination | Uniprot | |
| K723 | Ubiquitination | Uniprot | |
| T730 | Phosphorylation | Uniprot | |
| S735 | Phosphorylation | Uniprot | |
| T739 | Phosphorylation | Uniprot | |
| S749 | Phosphorylation | Uniprot | |
| R751 | Methylation | Uniprot | |
| S753 | Phosphorylation | Uniprot | |
| T754 | Phosphorylation | Uniprot | |
| S765 | Phosphorylation | Uniprot | |
| S768 | Phosphorylation | Uniprot | |
| S772 | Phosphorylation | Uniprot | |
| S775 | Phosphorylation | Uniprot | |
| T776 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| S789 | Phosphorylation | Uniprot | |
| K790 | Ubiquitination | Uniprot | |
| S795 | Phosphorylation | Uniprot | |
| T797 | Phosphorylation | Uniprot | |
| K803 | Ubiquitination | Uniprot | |
| K806 | Ubiquitination | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| T819 | Phosphorylation | Uniprot | |
| K825 | Ubiquitination | Uniprot | |
| K838 | Ubiquitination | Uniprot | |
| K844 | Ubiquitination | Uniprot | |
| K851 | Acetylation | Uniprot | |
| K851 | Ubiquitination | Uniprot | |
| K871 | Ubiquitination | Uniprot | |
| K875 | Ubiquitination | Uniprot | |
| K887 | Ubiquitination | Uniprot | |
| S894 | Phosphorylation | Uniprot |
研究背景
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).
Sumoylated with SUMO1.
Nucleus.
Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity). Interacts with EP300; the interaction is detected in activated T-lymphocytes, but not under resting conditions.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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