| 产品: | TSYL2 抗体 |
| 货号: | DF2466 |
| 描述: | Rabbit polyclonal antibody to TSYL2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 79kDa; 79kD(Calculated). |
| 蛋白号: | Q9H2G4 |
| RRID: | AB_2839672 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2466, RRID:AB_2839672.
展开/折叠
CASK interacting nucleosome assembly protein; CDA1; Cell division autoantigen 1; CINAP; CTCL; CTCL tumor antigen se20 4; CTCL-associated antigen se20-4; Cutaneous T cell lymphoma associated antigen se20 4; Cutaneous T cell lymphoma associated tumor antigen se20 4; Cutaneous T-cell lymphoma-associated antigen se20-4; Differentially Expressed Nucleolar TGF beta1 Target; Differentially Expressed Nucleolar TGF beta1 Target protein; Differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; Nuclear protein of 79 kDa; RP1 290F12.2; SE20 4; SE204; Testis specific protein Y encoded like 2; testis-specific protein Y encoded-like 2; Testis-specific Y-encoded-like protein 2; TSPX; TSPY like 2; TSPY like protein 2; TSPY-like protein 2; TSPYL2; TSYL2_HUMAN;
抗原和靶标
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
- Q9H2G4 TSYL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG
翻译修饰 - Q9H2G4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Ubiquitination | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S182 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| T340 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K384 | Ubiquitination | Uniprot | |
| K407 | Methylation | Uniprot | |
| K414 | Acetylation | Uniprot |
研究背景
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
Nucleus. Cytoplasm.
Note: Enriched in transcriptionally active regions of chromatin in neurons.
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).
Belongs to the nucleosome assembly protein (NAP) family.
限制条款
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