FGF5 Antibody - #DF2496

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产品: FGF5 抗体
货号: DF2496
描述: Rabbit polyclonal antibody to FGF5
应用: WB
反应: Human, Mouse, Rat
分子量: 30 kDa; 30kD(Calculated).
蛋白号: P12034
RRID: AB_2839702

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
FGF5 Antibody detects endogenous levels of total FGF5.
RRID:
AB_2839702
引用格式: Affinity Biosciences Cat# DF2496, RRID:AB_2839702.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FGF 5; FGF-5; FGF5; FGF5_HUMAN; Fibroblast growth factor 5; HBGF 5; HBGF-5; heparin binding growth factor 5; Heparin-binding growth factor 5; Smag 82; Smag-82; TCMGLY;

抗原和靶标

免疫原:
Uniprot:

P12034(FGF5_HUMAN) >>Visit HPA database.

基因/基因ID:
FGF5(2250)
表达:
P12034 FGF5_HUMAN:

Expressed in neonatal brain.

描述:
Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
序列:
MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG

翻译修饰 - P12034 作为底物

Site PTM Type Enzyme
S250 Phosphorylation

研究背景

功能:

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in neonatal brain.

亚基结构:

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

蛋白家族:

Belongs to the heparin-binding growth factors family.

研究领域

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Melanoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

文献引用

1). Hair growth predicts a depression-like phenotype in rats as a mirror of stress traceability. NEUROCHEMISTRY INTERNATIONAL, 2021 (PubMed: 34166749) [IF=4.2]

Application: WB    Species: Rat    Sample: Hippocampus tissue

Fig. 5. Down-regulation of the glucocorticoid re- ceptor (GR), fibroblast growth factor 2 (FGF2), brain-derived neurotrophic factor (BDNF) expres- sion in the hippocampus, and fibroblast growth factor 5 (FGF5) expression in the skin of stressed rats. (A) Western blotting and quantification of GR, FGF2, and BDNF expression in the hippocampus; (B) Western blotting and quantification of FGF5 expression in the skin. All data are shown as mean ± SEM; n = 4; * denotes significance compared with control, *p < 0.05, ***p < 0.001.
2). WITHDRAWN: Circ_0041732 regulates tumor progression and angiogenesis by miR-149-5p/FGF5 pathway in triple negative breast cancer. Pathology - Research and Practice, 2021 [IF=2.8]

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