| 产品: | ST2 抗体 |
| 货号: | DF2533 |
| 描述: | Rabbit polyclonal antibody to ST2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 分子量: | 70 kDa; 63kD(Calculated). |
| 蛋白号: | Q01638 |
| RRID: | AB_2839739 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2533, RRID:AB_2839739.
展开/折叠
DER-4; DER4; FIT 1; Growth stimulation expressed; homolog of mouse growth stimulation-expressed; Il1rl1; IL33R; ILRL1_HUMAN; Interleukin 1 receptor like 1; interleukin 1 receptor related protein; Interleukin-1 receptor-like 1; Protein ST2; ST2; ST2L; ST2V; T1; T1 protein;
抗原和靶标
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
- Q01638 ILRL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ
翻译修饰 - Q01638 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N95 | N-Glycosylation | Uniprot | |
| N140 | N-Glycosylation | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| Y179 | Phosphorylation | Uniprot | |
| N191 | N-Glycosylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| T370 | Phosphorylation | Uniprot | |
| Y377 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| Y533 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S546 | Phosphorylation | Uniprot |
研究背景
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
Inhibits IL-33 signaling.
Cell membrane.
Secreted.
Cell membrane>Single-pass type I membrane protein.
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Belongs to the interleukin-1 receptor family.
限制条款
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