| 产品: | IFNAR2 抗体 |
| 货号: | DF2535 |
| 描述: | Rabbit polyclonal antibody to IFNAR2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 57kDa; 58kD(Calculated). |
| 蛋白号: | P48551 |
| RRID: | AB_2839741 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2535, RRID:AB_2839741.
展开/折叠
Human interferon alpha/beta receptor; IFN alpha REC; IFN R; IFN-a/ßR2; IFN-a/ßRß; IFN-alpha binding protein; IFN-alpha/beta receptor 2; IFN-R-2; IFNABR; IFNAR2; IFNARB; IFNR; INAR2_HUMAN; Interferon (alpha beta and omega) receptor 2; Interferon alpha binding protein; Interferon alpha/beta receptor 2; Interferon alpha/beta receptor beta chain; Type I interferon receptor 2; Type I interferon receptor;
抗原和靶标
Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
- P48551 INAR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
翻译修饰 - P48551 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K80 | Ubiquitination | Uniprot | |
| N87 | N-Glycosylation | Uniprot | |
| N192 | N-Glycosylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| Y316 | Phosphorylation | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K399 | Acetylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| Y411 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| Y512 | Phosphorylation | Uniprot |
研究背景
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated.
Cell membrane>Single-pass type I membrane protein.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Heterodimer with IFNAR1. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1.
Belongs to the type II cytokine receptor family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Toll-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
限制条款
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