| 产品: | JAM1 抗体 |
| 货号: | DF2549 |
| 描述: | Rabbit polyclonal antibody to JAM1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Horse, Sheep, Rabbit, Dog |
| 分子量: | 33 kDa; 33kD(Calculated). |
| 蛋白号: | Q9Y624 |
| RRID: | AB_2839755 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2549, RRID:AB_2839755.
展开/折叠
CD 321; CD321; CD321 antigen; ESTM33; F11 receptor; F11R; JAM 1; JAM A; JAM; JAM-1; JAM-A; JAM1; JAM1_HUMAN; JAMA; JCAM; Jcam1; Junction adhesion molecule 1; Junction adhesion molecule, mouse, homolog of; Junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM 1; PAM-1; PAM1; Platelet adhesion molecule 1; Platelet adhesion molecule; Platelet F11 receptor; PRO301; UNQ264;
抗原和靶标
- Q9Y624 JAM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y624 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R86 | Methylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| T175 | O-Glycosylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| N185 | N-Glycosylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| T273 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S287 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot |
研究背景
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
N-glycosylated.
Cell junction>Tight junction. Cell membrane>Single-pass type I membrane protein.
Note: Localized at tight junctions of both epithelial and endothelial cells.
Expressed in endothelium, epithelium and leukocytes (at protein level).
Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with ITGAL (via I-domain).
(Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.
(Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.
The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
Belongs to the immunoglobulin superfamily.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Epithelial cell signaling in Helicobacter pylori infection.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
限制条款
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