产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2563, RRID:AB_2839769.
展开/折叠
bA421M1.5; FLJ20624; hPIP 1; hPIP1; MAK 11; MAK11; p21 activated protein kinase interacting protein 1; PAK- AND PLC-INTERACTING PROTEIN 1; PAK/PLC interacting protein 1; PAK1 interacting protein; PAK1IP1; PIP 1; PIP1; Putative PAK inhibitor Skb15; RP11 421M1.5; WD repeat containing protein 84; WDR 84; WDR84;
抗原和靶标
Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
- Q9NWT1 PK1IP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ
翻译修饰 - Q9NWT1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K70 | Acetylation | Uniprot | |
| K111 | Acetylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| T127 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| Y179 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| K372 | Acetylation | Uniprot | |
| K381 | Acetylation | Uniprot |
研究背景
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Nucleus>Nucleolus.
Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
Interacts with PAK1.
限制条款
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