HRB Antibody - #DF2639

>>50ul送剥离液 进行中>>
>>100ul送二抗 进行中>>
(1)  
产品: HRB 抗体
货号: DF2639
描述: Rabbit polyclonal antibody to HRB
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Xenopus
分子量: 58 kDa; 58kD(Calculated).
蛋白号: P52594
RRID: AB_2839845

浏览相似产品>>

   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

联系销售
相关下载
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
HRB Antibody detects endogenous levels of total HRB.
RRID:
AB_2839845
引用格式: Affinity Biosciences Cat# DF2639, RRID:AB_2839845.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AGFG1; AGFG1_HUMAN; Arf-GAP domain and FG repeats-containing protein 1; ArfGAP with FG repeats 1; AU045498; C130049H11Rik; C85612; D730048C23Rik; DKFZp686I15205; HIV 1 Rev binding protein; HIV-1 Rev-binding protein; HRB; MGC116375; MGC116938; MGC116940; Nucleoporin like protein RIP; Nucleoporin-like protein RIP; RAB; Rev interacting protein; Rev-interacting protein; Rev/Rex activation domain-binding protein; RIP;

抗原和靶标

免疫原:
Uniprot:

P52594(AGFG1_HUMAN) >>Visit HPA database.

基因/基因ID:
AGFG1(3267)
表达:
P52594 AGFG1_HUMAN:

Ubiquitously expressed.

描述:
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
序列:
MAASAKRKQEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSSAIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKSLLGDSAPTLHLNKGTPSQSPVVGRSQGQQQEKKQFDLLSDLGSDIFAAPAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQTTGGSAASVNANFAHFDNFPKSSSADFGTFNTSQSHQTASAVSKVSTNKAGLQTADKYAALANLDNIFSAGQGGDQGSGFGTTGKAPVGSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQPASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQTKPVVTPFGQVAAAGVSSNPFMTGAPTGQFPTGSSSTNPFL

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Xenopus
100
Horse
0
Sheep
0
Dog
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P52594 作为底物

Site PTM Type Enzyme
R18 Methylation
Y39 Phosphorylation
K83 Ubiquitination
K114 Ubiquitination
K120 Acetylation
K120 Ubiquitination
K123 Acetylation
K124 Acetylation
S142 Phosphorylation
S144 Phosphorylation
S146 Phosphorylation
S147 Phosphorylation
S149 Phosphorylation
T151 Phosphorylation
T154 Phosphorylation
K161 Methylation
S162 Phosphorylation
S167 Phosphorylation
T170 Phosphorylation
K175 Ubiquitination
T177 Phosphorylation
S179 Phosphorylation
S181 Phosphorylation
K194 Acetylation
S291 Phosphorylation
S293 Phosphorylation
T298 Phosphorylation
T301 Phosphorylation
S302 Phosphorylation
S304 Phosphorylation
T307 Phosphorylation
K313 Ubiquitination
K318 Ubiquitination
T323 Phosphorylation
Y327 Phosphorylation
S362 Phosphorylation
S365 Phosphorylation
S368 Phosphorylation
R456 Methylation
Y480 Phosphorylation
T544 Phosphorylation
S556 Phosphorylation
S557 Phosphorylation
T558 Phosphorylation

研究背景

功能:

Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.

翻译修饰:

O-glycosylated.

细胞定位:

Nucleus. Cytoplasmic vesicle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitously expressed.

亚基结构:

Interacts with EPS15R and EPS15. Interacts with FCHO1.

蛋白家族:

Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.

研究领域

· Human Diseases > Infectious diseases: Viral > Influenza A.

限制条款

产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）

产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.