| 产品: | PTK7 抗体 |
| 货号: | DF2659 |
| 描述: | Rabbit polyclonal antibody to PTK7 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 86 kDa; 118kD(Calculated). |
| 蛋白号: | Q13308 |
| RRID: | AB_2839865 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2659, RRID:AB_2839865.
展开/折叠
8430404F20Rik; CCK 4; CCK-4; Colon carcinoma kinase 4; Human colon carcinoma kinase 4 (CCK4) mRNA complete cds; Inactive tyrosine-protein kinase 7; mPTK7/CCK4; OTTHUMP00000217016; Protein tyrosine kinase PTK 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK 7; PTK7; PTK7 protein tyrosine kinase 7; PTK7 protein tyrosine kinase; PTK7_HUMAN; Serum response factor; Srf; Tyrosine-protein kinase-like 7;
抗原和靶标
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
- Q13308 PTK7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13308 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| N116 | N-Glycosylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| N175 | N-Glycosylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| N268 | N-Glycosylation | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| N283 | N-Glycosylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| K636 | Ubiquitination | Uniprot | |
| N646 | N-Glycosylation | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| T785 | Phosphorylation | Uniprot | |
| S786 | Phosphorylation | Uniprot | |
| K788 | Ubiquitination | Uniprot | |
| S795 | Phosphorylation | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| K830 | Ubiquitination | Uniprot | |
| K835 | Ubiquitination | Uniprot | |
| Y872 | Phosphorylation | Uniprot | |
| Y877 | Phosphorylation | Uniprot | |
| K898 | Ubiquitination | Uniprot | |
| K905 | Ubiquitination | Uniprot | |
| K929 | Ubiquitination | Uniprot | |
| K945 | Ubiquitination | Uniprot | |
| S958 | Phosphorylation | Uniprot | |
| Y960 | Phosphorylation | Uniprot | |
| Y961 | Phosphorylation | Uniprot | |
| K1035 | Ubiquitination | Uniprot | |
| K1069 | Ubiquitination | Uniprot |
研究背景
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Membrane>Single-pass type I membrane protein. Cell junction.
Note: Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Interacts with CTNNB1.
The protein kinase domain is predicted to be catalytically inactive.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
限制条款
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