| 产品: | CSNK2A2 抗体 |
| 货号: | DF2661 |
| 描述: | Rabbit polyclonal antibody to CSNK2A2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Chicken, Xenopus |
| 分子量: | 41 kDa; 41kD(Calculated). |
| 蛋白号: | P19784 |
| RRID: | AB_2839867 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2661, RRID:AB_2839867.
展开/折叠
Casein kinase 2 alpha prime polypeptide; Casein kinase II alpha' chain; Casein kinase II subunit alpha'; CK II alpha'; CK II; CK2A2; CKII; CSK22_HUMAN; CSNK2A1; CSNK2A2; FLJ43934;
抗原和靶标
- P19784 CSK22_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P19784 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y13 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| K50 | Acetylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| R90 | Methylation | Uniprot | |
| K97 | Acetylation | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| Y240 | Phosphorylation | Uniprot | |
| Y256 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| C336 | S-Nitrosylation | Uniprot | |
| S343 | Phosphorylation | Uniprot |
翻译修饰 - P19784 作为激酶
| Substrate | Site | Source |
|---|---|---|
| O14958-1 (CASQ2) | S385 | Uniprot |
| O43896 (KIF1C) | S1092 | Uniprot |
| P01106-2 (MYC) | T73 | Uniprot |
| P04198 (MYCN) | S261 | Uniprot |
| P04198 (MYCN) | S263 | Uniprot |
| P04818 (TYMS) | S124 | Uniprot |
| P07910-2 (HNRNPC) | S247 | Uniprot |
| P07910-1 (HNRNPC) | S260 | Uniprot |
| P09497-1 (CLTB) | S11 | Uniprot |
| P09497-1 (CLTB) | S13 | Uniprot |
| P10451-5 (SPP1) | S148 | Uniprot |
| P11836 (MS4A1) | S231 | Uniprot |
| P11836 (MS4A1) | T250 | Uniprot |
| P11836 (MS4A1) | S289 | Uniprot |
| P13349 (MYF5) | S49 | Uniprot |
| P13349 (MYF5) | S133 | Uniprot |
| P17096-2 (HMGA1) | S88 | Uniprot |
| P17096-2 (HMGA1) | S91 | Uniprot |
| P17096-2 (HMGA1) | S92 | Uniprot |
| P17096-1 (HMGA1) | S99 | Uniprot |
| P17096-1 (HMGA1) | S102 | Uniprot |
| P17096-1 (HMGA1) | S103 | Uniprot |
| P17931 (LGALS3) | S6 | Uniprot |
| P17931 (LGALS3) | S12 | Uniprot |
| P18031 (PTPN1) | S352 | Uniprot |
| P18031 (PTPN1) | S378 | Uniprot |
| P18031 (PTPN1) | S386 | Uniprot |
| P18887 (XRCC1) | S485 | Uniprot |
| P18887 (XRCC1) | T488 | Uniprot |
| P18887 (XRCC1) | S518 | Uniprot |
| P18887 (XRCC1) | T519 | Uniprot |
| P18887 (XRCC1) | T523 | Uniprot |
| P21673 (SAT1) | T10 | Uniprot |
| P21673 (SAT1) | S146 | Uniprot |
| P21673 (SAT1) | S149 | Uniprot |
| P24534 (EEF1B2) | S106 | Uniprot |
| P24534 (EEF1B2) | S112 | Uniprot |
| P32121-1 (ARRB2) | T382 | Uniprot |
| P35222 (CTNNB1) | S29 | Uniprot |
| P35222 (CTNNB1) | T102 | Uniprot |
| P35222 (CTNNB1) | T112 | Uniprot |
| P37840-1 (SNCA) | S129 | Uniprot |
| P41236 (PPP1R2) | S87 | Uniprot |
| P41236 (PPP1R2) | S121 | Uniprot |
| P41236 (PPP1R2) | S122 | Uniprot |
| P42768 (WAS) | S483 | Uniprot |
| P42768 (WAS) | S484 | Uniprot |
| P49795 (RGS19) | S24 | Uniprot |
| P51946 (CCNH) | T315 | Uniprot |
| P52655-2 (GTF2A1) | S241 | Uniprot |
| P52655-2 (GTF2A1) | S242 | Uniprot |
| P52655-2 (GTF2A1) | S277 | Uniprot |
| P52655-1 (GTF2A1) | S280 | Uniprot |
| P52655-1 (GTF2A1) | S281 | Uniprot |
| P52655-2 (GTF2A1) | S282 | Uniprot |
| P52655-1 (GTF2A1) | S316 | Uniprot |
| P52655-1 (GTF2A1) | S321 | Uniprot |
| P55087-1 (AQP4) | S276 | Uniprot |
| P55087-1 (AQP4) | S285 | Uniprot |
| P55087-1 (AQP4) | S316 | Uniprot |
| P55957-1 (BID) | T59 | Uniprot |
| P55957-1 (BID) | S64 | Uniprot |
| P60484-1 (PTEN) | T366 | Uniprot |
| P60484-1 (PTEN) | S370 | Uniprot |
| P67870 (CSNK2B) | S2 | Uniprot |
| P67870 (CSNK2B) | S3 | Uniprot |
| P84090 (ERH) | T18 | Uniprot |
| P84090 (ERH) | S24 | Uniprot |
| Q00613 (HSF1) | T142 | Uniprot |
| Q01105-2 (SET) | S9 | Uniprot |
| Q01892-1 (SPIB) | S37 | Uniprot |
| Q01892-1 (SPIB) | S129 | Uniprot |
| Q01892 (SPIB) | S144 | Uniprot |
| Q01892 (SPIB) | S146 | Uniprot |
| Q03060-16 (CREM) | T63 | Uniprot |
| Q03060-16 (CREM) | S110 | Uniprot |
| Q03135-1 (CAV1) | S88 | Uniprot |
| Q05940-1 (SLC18A2) | S511 | Uniprot |
| Q12972-2 (PPP1R8) | T19 | Uniprot |
| Q12972-2 (PPP1R8) | S62 | Uniprot |
| Q12972-1 (PPP1R8) | T161 | Uniprot |
| Q12972-1 (PPP1R8) | S204 | Uniprot |
| Q13085-1 (ACACA) | S29 | Uniprot |
| Q13085-4 (ACACA) | S66 | Uniprot |
| Q13144 (EIF2B5) | S717 | Uniprot |
| Q13144 (EIF2B5) | S718 | Uniprot |
| Q13541 (EIF4EBP1) | S112 | Uniprot |
| Q13547 (HDAC1) | S421 | Uniprot |
| Q13547 (HDAC1) | S423 | Uniprot |
| Q14005-3 (IL16) | S42 | Uniprot |
| Q14005-1 (IL16) | S743 | Uniprot |
| Q16543 (CDC37) | S13 | Uniprot |
| Q16623-1 (STX1A) | S14 | Uniprot |
| Q6FHW4 (TCF7L2) | S58 | Uniprot |
| Q6FHW4 (TCF7L2) | S59 | Uniprot |
| Q6FHW4 (TCF7L2) | S60 | Uniprot |
| Q712K3 (UBE2R2) | S233 | Uniprot |
| Q92598-1 (HSPH1) | S509 | Uniprot |
| Q92769 (HDAC2) | S394 | Uniprot |
| Q92769 (HDAC2) | S422 | Uniprot |
| Q92769 (HDAC2) | S424 | Uniprot |
| Q96SB4 (SRPK1) | S51 | Uniprot |
| Q96SB4 (SRPK1) | S555 | Uniprot |
| Q99801 (NKX3-1) | T89 | Uniprot |
| Q99801 (NKX3-1) | T93 | Uniprot |
| Q9NZU7-2 (CABP1) | S120 | Uniprot |
| Q9NZU7-1 (CABP1) | S180 | Uniprot |
| Q9UD71-2 (PPP1R1B) | S9 | Uniprot |
| Q9UD71-1 (PPP1R1B) | S45 | Uniprot |
| Q9UD71-2 (PPP1R1B) | S66 | Uniprot |
| Q9UD71-1 (PPP1R1B) | S102 | Uniprot |
| Q9UNN4-1 (GTF2A1L) | S356 | Uniprot |
| Q9UNN4-1 (GTF2A1L) | S357 | Uniprot |
| Q9UNN4-1 (GTF2A1L) | S418 | Uniprot |
| Q9UNN4-1 (GTF2A1L) | S423 | Uniprot |
| Q9UQE7 (SMC3) | S1067 | Uniprot |
| Q9Y5B0-1 (CTDP1) | S575 | Uniprot |
| Q9Y5B0 (CTDP1) | S740 | Uniprot |
研究背景
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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