PRKD3 Antibody - #DF2674

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产品: PRKD3 抗体
货号: DF2674
描述: Rabbit polyclonal antibody to PRKD3
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Sheep, Rabbit, Dog
分子量: 107 kDa,; 100kD(Calculated).
蛋白号: O94806
RRID: AB_2839880

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
PRKD3 Antibody detects endogenous levels of total PRKD3.
RRID:
AB_2839880
引用格式: Affinity Biosciences Cat# DF2674, RRID:AB_2839880.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EPK 2; EPK2; KPCD3_HUMAN; nPKC nu; nPKC-nu; nPKCnu; nu; PKCnu; PKD 3; PKD3; PRK D3; PRKCN; PRKD 3; Prkd3; Protein kinase C; Protein kinase C nu; Protein kinase C nu type; Protein kinase D3; Protein kinase EPK 2; Protein kinase EPK2; Serine threonine protein kinase; Serine/threonine protein kinase D3; Serine/threonine-protein kinase D3;

抗原和靶标

免疫原:
Uniprot:

O94806(KPCD3_HUMAN) >>Visit HPA database.

基因/基因ID:
PRKD3(23683)
表达:
O94806 KPCD3_HUMAN:

Ubiquitous.

描述:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.;
序列:
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
75
Pig
44
Horse
44
Zebrafish
44
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - O94806 作为底物

Site PTM Type Enzyme
S2 Phosphorylation
S6 Phosphorylation
S9 Phosphorylation
S13 Phosphorylation
S27 Phosphorylation
S30 Phosphorylation
S31 Phosphorylation
T34 Phosphorylation
S37 Phosphorylation
S41 Phosphorylation
S44 Phosphorylation
S46 Phosphorylation
S213 Phosphorylation
S216 Phosphorylation
S252 Phosphorylation
S254 Phosphorylation
K293 Ubiquitination
S315 Phosphorylation
T360 Phosphorylation
S364 Phosphorylation
T389 Phosphorylation
S391 Phosphorylation
S395 Phosphorylation
S406 Phosphorylation
K408 Ubiquitination
S415 Phosphorylation
T446 Phosphorylation
Y456 Phosphorylation
S463 Phosphorylation
T535 Phosphorylation
S543 Phosphorylation
K605 Ubiquitination
K615 Ubiquitination
K730 Ubiquitination
S731 Phosphorylation P17252 (PRKCA)
S735 Phosphorylation
T739 Phosphorylation
Y742 Phosphorylation
K816 Ubiquitination

翻译修饰 - O94806 作为激酶

Substrate Site Source
P49840 (GSK3A) S21 Uniprot
P49841 (GSK3B) S9 Uniprot
Q04206 (RELA) S276 Uniprot
Q04206 (RELA) S536 Uniprot
Q15139 (PRKD1) S738 Uniprot
Q15139 (PRKD1) S742 Uniprot
Q9BST9 (RTKN) S448 Uniprot
Q9NRA0 (SPHK2) S419 Uniprot
Q9NRA0 (SPHK2) S421 Uniprot
Q9UQL6 (HDAC5) S498 Uniprot
Q9Y2X7 (GIT1) S46 Uniprot

研究背景

功能:

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

细胞定位:

Cytoplasm. Membrane.
Note: Translocation to the cell membrane is required for kinase activation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous.

蛋白家族:

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

研究领域

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

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