| 产品: | PKN3 抗体 |
| 货号: | DF2678 |
| 描述: | Rabbit polyclonal antibody to PKN3 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog |
| 分子量: | 99kDa,112kDa,104kDa; 99kD(Calculated). |
| 蛋白号: | Q6P5Z2 |
| RRID: | AB_2839884 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2678, RRID:AB_2839884.
展开/折叠
pkn3; PKN3_HUMAN; PKNBETA; Protein kinase C related kinase 3; Protein kinase N3; Protein kinase PKN beta; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; RP11-545E17.1; Serine/threonine protein kinase N3; Serine/threonine-protein kinase N3;
抗原和靶标
Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
- Q6P5Z2 PKN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6P5Z2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K20 | Ubiquitination | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| R58 | Methylation | Uniprot | |
| T135 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| T480 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| T492 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| T508 | Phosphorylation | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| T523 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| T527 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Q6P5Z2 (PKN3) | Uniprot |
| S548 | Phosphorylation | Uniprot | |
| T550 | Phosphorylation | Q6P5Z2 (PKN3) | Uniprot |
| K583 | Acetylation | Uniprot | |
| K583 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K592 | Ubiquitination | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| T716 | Phosphorylation | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| T718 | Phosphorylation | Uniprot | |
| T722 | Phosphorylation | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| K813 | Ubiquitination | Uniprot | |
| T820 | Phosphorylation | Uniprot | |
| T860 | Phosphorylation | Uniprot |
翻译修饰 - Q6P5Z2 作为激酶
研究背景
Contributes to invasiveness in malignant prostate cancer.
Autophosphorylated.
Nucleus. Cytoplasm>Perinuclear region.
Note: Nuclear and perinuclear Golgi region.
Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
The C1 domain does not bind the diacylglycerol (DAG).
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
研究领域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
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