| 产品: | BECN1L1 抗体 |
| 货号: | DF2696 |
| 描述: | Rabbit polyclonal antibody to BECN1L1 |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 48kDa; 48kD(Calculated). |
| 蛋白号: | A8MW95 |
| RRID: | AB_2839902 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2696, RRID:AB_2839902.
抗原和靶标
- A8MW95 BECN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQDGASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKWSLIWVASRYQK
翻译修饰 - A8MW95 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y347 | Phosphorylation | Uniprot |
研究背景
Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.
Cytoplasm.
Present in fetal and adult brain (at protein level).
Homodimer (via coiled-coil domain). Interacts (via coiled-coil domain) with ATG14 (via coiled-coil domain); this interaction is tighter than BECN2 self-association. Interacts with AMBRA1, UVRAG and PIK3C3/VPS34; these interactions are not disrupted by starvation. Does not interact with RUBCN. Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct.
Belongs to the beclin family.
研究领域
· Cellular Processes > Transport and catabolism > Autophagy - other. (View pathway)
· Cellular Processes > Transport and catabolism > Autophagy - animal. (View pathway)
· Cellular Processes > Cell growth and death > Apoptosis - multiple species. (View pathway)
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
限制条款
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