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| 产品: | GPR161 抗体 |
| 货号: | DF2798 |
| 描述: | Rabbit polyclonal antibody to GPR161 |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 65 kDa; 59kD(Calculated). |
| 蛋白号: | Q8N6U8 |
| RRID: | AB_2840004 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2798, RRID:AB_2840004.
展开/折叠
G protein coupled receptor 161; G protein coupled receptor RE2; RE2;
抗原和靶标
- Q8N6U8 GP161_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8N6U8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y57 | Phosphorylation | Uniprot | |
| T226 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| T490 | Phosphorylation | Uniprot | |
| T493 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot |
研究背景
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Cell projection>Cilium membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
Note: Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
文献引用
Application: IHC Species: Rat Sample: lung
限制条款
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