(1)
(3)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0154, RRID:AB_2833335.
展开/折叠
COFS 4; COFS4; DNA excision repair protein ERCC 1; DNA excision repair protein ERCC-1; DNA excision repair protein ERCC1; ERCC 1; ERCC1; ERCC1_HUMAN; Excision repair cross complementation group 1; Excision repair cross complementing 1; Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1; Excision repair protein; RAD 10; RAD10; UV 20; UV20;
抗原和靶标
- P07992 ERCC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPGKDKEGVPQPSGPPARKKFVIPLDEDEVPPGVAKPLFRSTQSLPTVDTSAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQKARRLFDVLHEPFLKVP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P07992 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Ubiquitination | Uniprot | ||
| M1 | Acetylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| K37 | Acetylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K295 | Acetylation | Uniprot | |
| K295 | Ubiquitination | Uniprot |
研究背景
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Nucleus.
Cytoplasm. Nucleus.
Nucleus.
Nucleus.
Heterodimer composed of ERCC1 isoform 1 and XPF/ERRC4.
Belongs to the ERCC1/RAD10/SWI10 family.
研究领域
· Genetic Information Processing > Replication and repair > Nucleotide excision repair.
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
文献引用
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