产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0158, RRID:AB_2833339.
展开/折叠
FGFR1 oncogene partner; FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN; OTTHUMP00000017612; OTTHUMP00000017613;
抗原和靶标
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
- O95684 FR1OP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHSPPKSPEGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVADYLEDVA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95684 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T4 | Phosphorylation | Uniprot | |
| T55 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| T170 | Phosphorylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| K182 | Acetylation | Uniprot | |
| K183 | Acetylation | Uniprot | |
| K184 | Acetylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| K214 | Acetylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| K323 | Ubiquitination | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| Y394 | Phosphorylation | Uniprot |
研究背景
Required for anchoring microtubules to the centrosomes. Required for ciliation.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytoskeleton>Cilium basal body.
Note: Associated with gamma-tubulin (PubMed:16314388). Localizes on both mother and daughter centrioles (PubMed:28625565, PubMed:28428259). Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole partly on the subdistal appendage region (PubMed:28659385).
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1. Interacts with CEP19. Interacts (via N-terminus) with CEP350 (via C-terminus).
Belongs to the FGFR1OP family.
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